Can't find a trace of it today, or any indication of whether it became something else. There's another motel at the intersection of I-270 and Highway 157, but it's a three-story Hampton or Comfort or Something Inn. Certainly not a supermodern two-story motel with pink doors.

If only there was a giant database of past Holiday Inns. These things just disappear, which seems wrong.

True:

For Jackson Browne’s 1977 platinum album, Running On Empty, Browne recorded much of it on the road including a few tracks in hotel rooms. “Shaky Town” and “Cocaine” were recorded in room 124 in the Edwardsville, IL Holiday Inn.