Can't find a trace of it today, or any indication of whether it became something else. There's another motel at the intersection of I-270 and Highway 157, but it's a three-story Hampton or Comfort or Something Inn. Certainly not a supermodern two-story motel with pink doors.
If only there was a giant database of past Holiday Inns. These things just disappear, which seems wrong.
For Jackson Browne’s 1977 platinum album, Running On Empty, Browne recorded much of it on the road including a few tracks in hotel rooms. “Shaky Town” and “Cocaine” were recorded in room 124 in the Edwardsville, IL Holiday Inn.